Effects of stress response induced by laparoscopic colectomy and laparotomy on TLR-mediated innate immune responses in colon cancer patients

Abstract Objectives Colon cancer patients were analyzed to compare the effects of surgical trauma on immune function by detecting activation degree cell inflammatory cytokines levels after different procedures. Methods In total, 107 with colon divided into open surgery group and laparoscopic group. Serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), toll-like receptor 4 (TLR4), cluster differentiation 14 (CD14) myeloid protein-2 (MD-2) detected before, one day surgery. Results CRP, IL-6 TNF-α in both groups significantly increased at all postoperative time points compared those preoperatively. lower than that LPS stimulation. Laparoscopic led decrease serum CD14, TLR4 MD-2 levels. The incidence complications was less as Conclusions Cellular immunity may be better presented comparison complete mesenteric resection is effective treatment cancer.